Major Histocompatibility Complex Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells
Identifieur interne : 000D61 ( Main/Exploration ); précédent : 000D60; suivant : 000D62Major Histocompatibility Complex Class II Expression and Hemagglutinin Subtype Influence the Infectivity of Type A Influenza Virus for Respiratory Dendritic Cells
Auteurs : Kristian M. Hargadon [États-Unis] ; HAIXIA ZHOU [États-Unis] ; Randy A. Albrecht [États-Unis] ; Haley A. Dodd [États-Unis] ; Adolfo Garcia-Sastre [États-Unis] ; Thomas J. Braciale [États-Unis]Source :
- Journal of virology [ 0022-538X ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
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Abstract
Dendritic cells (DC) play a key role in antiviral immunity, functioning both as innate effector cells in early phases of the immune response and subsequently as antigen-presenting cells that activate the adaptive immune response. In the murine respiratory tract, there are several respiratory dendritic cell (RDC) subsets, including CD103+ DC, CD11bhi DC, monocyte/macrophage DC, and plasmacytoid DC. However, little is known about the interaction between these tissue-resident RDC and viruses that are encountered during natural infection in the respiratory tract. Here, we show both in vitro and in vivo that the susceptibility of murine RDC to infection with type A influenza virus varies with the level of MHC class II expression by RDC and with the virus strain. Both CD103+ and CD11bhi RDC, which express the highest basal level of major histocompatibility complex (MHC) class II, are highly susceptible to infection by type A influenza virus. However, efficient infection is restricted to type A influenza virus strains of the H2N2 subtype. Furthermore, enhanced infectivity by viruses of the H2N2 subtype is linked to expression of the I-E MHC class II locus product. These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract.
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Braciale</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>The Carter Immunology Center, University of Virginia Health Sciences Center</s1><s2>Charlottesville, Virginia 22908</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, Virginia 22908</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Pathology, University of Virginia Health Sciences Center</s1><s2>Charlottesville, Virginia 22908</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, Virginia 22908</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Microbiology, University of Virginia Health Sciences Center</s1><s2>Charlottesville, Virginia 22908</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Charlottesville, Virginia 22908</wicri:noRegion></affiliation><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Microbiology, Mount Sinai School of Medicine, 1468 Madison Avenue, New York</s1><s2>New York 10029-6574</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Dendritic cell</term><term>Hemagglutinin</term><term>Infectivity</term><term>Influenza A virus</term><term>Major histocompatibility system</term><term>Subtype</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term><term>Système histocompatibilité majeur</term><term>Hémagglutinine</term><term>Soustype</term><term>Pouvoir infectant</term><term>Cellule dendritique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dendritic cells (DC) play a key role in antiviral immunity, functioning both as innate effector cells in early phases of the immune response and subsequently as antigen-presenting cells that activate the adaptive immune response. In the murine respiratory tract, there are several respiratory dendritic cell (RDC) subsets, including CD103<sup>+</sup> DC, CD11b<sup>hi </sup>DC, monocyte/macrophage DC, and plasmacytoid DC. However, little is known about the interaction between these tissue-resident RDC and viruses that are encountered during natural infection in the respiratory tract. Here, we show both in vitro and in vivo that the susceptibility of murine RDC to infection with type A influenza virus varies with the level of MHC class II expression by RDC and with the virus strain. Both CD103<sup>+</sup> and CD11b<sup>hi </sup>RDC, which express the highest basal level of major histocompatibility complex (MHC) class II, are highly susceptible to infection by type A influenza virus. However, efficient infection is restricted to type A influenza virus strains of the H2N2 subtype. Furthermore, enhanced infectivity by viruses of the H2N2 subtype is linked to expression of the I-E MHC class II locus product. These results suggest a potential novel role for MHC class II molecules in influenza virus infection and pathogenesis in the respiratory tract.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><noRegion><name sortKey="Hargadon, Kristian M" sort="Hargadon, Kristian M" uniqKey="Hargadon K" first="Kristian M." last="Hargadon">Kristian M. Hargadon</name></noRegion><name sortKey="Albrecht, Randy A" sort="Albrecht, Randy A" uniqKey="Albrecht R" first="Randy A." last="Albrecht">Randy A. Albrecht</name><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J." last="Braciale">Thomas J. Braciale</name><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J." last="Braciale">Thomas J. Braciale</name><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J." last="Braciale">Thomas J. Braciale</name><name sortKey="Braciale, Thomas J" sort="Braciale, Thomas J" uniqKey="Braciale T" first="Thomas J." last="Braciale">Thomas J. Braciale</name><name sortKey="Dodd, Haley A" sort="Dodd, Haley A" uniqKey="Dodd H" first="Haley A." last="Dodd">Haley A. Dodd</name><name sortKey="Dodd, Haley A" sort="Dodd, Haley A" uniqKey="Dodd H" first="Haley A." last="Dodd">Haley A. Dodd</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="Garcia-Sastre">Adolfo Garcia-Sastre</name><name sortKey="Garcia Sastre, Adolfo" sort="Garcia Sastre, Adolfo" uniqKey="Garcia Sastre A" first="Adolfo" last="Garcia-Sastre">Adolfo Garcia-Sastre</name><name sortKey="Haixia Zhou" sort="Haixia Zhou" uniqKey="Haixia Zhou" last="Haixia Zhou">HAIXIA ZHOU</name><name sortKey="Haixia Zhou" sort="Haixia Zhou" uniqKey="Haixia Zhou" last="Haixia Zhou">HAIXIA ZHOU</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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